Genetic variants and anterior cruciate ligament rupture – elastin proteins gene and fibromodulin gene polymorphisms

Introduction: Anterior cruciate ligament (ACL) injuries are among the most common of knee and often require reconstruction. The etiology molecular mechanisms rupture anterior is poorly understood, many external internal factors have been associated with it, including genetics. This study aimed to investigate association sequence variants in ELN FMOD candidate genes ACL ruptures based on essential biological functions these two proteoglycan-encoding maintaining structural integrity tissues regulating fibrillogenesis. Material Methods: partici-pants consisted 229 (164 male 65 female) individuals a surgically diagnosed rup-ture (ACLR) who qualified for reconstruction 192 (107 85 healthy participants no history injury (CON group). All ACLR group sustained through non-contact mechanisms. chi-square tests were used analysis rs2071307 rs7543148 between control (CON) group. Results: It follows from that tested athletes shows statistically significantly more frequent AA genotype gene polymorphism than However, looking at gender, one can observe frequent. In gene, rarer TT was observed compared and, similarly previous polymorphism, less males com-pared Conclusions: Genetic research sports, especially concerning connected characteristic polymorphic selected genes, justified, particularly as regards gender-homogenous groups.